Caution ought to be exercised when administering Promethazine HCl Oral Remedy to pediatric sufferers two yrs of age and older due to possible for fatal respiratory melancholy. Respiratory despair and apnea, sometimes affiliated with death, are strongly related to Promethazine products and are circuitously linked to individualized bodyweight-primarily based dosing, which might in any other case allow Harmless administration.
It is crucial that Promethazine HCl Oral Alternative is measured with the exact measuring system (see PRECAUTIONS-Data for Individuals). A household teaspoon is not an correct measuring gadget and could lead to overdosage, particularly when fifty percent a teaspoon is always to be measured.
Narcotics could produce adverse reactions which may obscure the scientific system of patients with head accidents.
Concomitant administration of promethazine merchandise with other respiratory depressants has an Affiliation with respiratory despair, and at times death, in pediatric individuals.
Selling or making a gift of Promethazine Hydrochloride and Codeine Phosphate Oral Resolution may perhaps damage others, and is in opposition to the regulation. Explain to your Health care supplier if you have ever abused or been dependent on alcohol, prescription medicines or Avenue medication.
“Physician purchasing” (checking out multiple prescribers to get added prescriptions) is frequent between drug abusers and other people suffering from untreated habit. Preoccupation with accomplishing satisfactory soreness reduction could be proper conduct in a patient with very poor agony Regulate.
When the patient develops these indicators or indicators, increase the dose for the previous degree and taper a lot more slowly, possibly by increasing the interval between decreases, decreasing the quantity of alter in dose, or the two.
Increased hazard of seizures. Promethazine HCl Oral Resolution needs to be used with caution in patients with seizures or that are on other medicines which can also boost the risk of seizures.
Labor or Shipping and delivery Opioids here cross the placenta and will deliver respiratory depression and psycho-physiologic effects in neonates. An opioid antagonist, for instance naloxone, should be accessible for reversal of opioid-induced respiratory despair in the neonate.
It truly is soluble in water and freely soluble in Liquor. It's got a molecular bodyweight of 320.88, a molecular components of C17H20N2S•HCl, and the next structural components:
Steer clear of the usage of Promethazine HCl and Codeine Phosphate Oral Alternative in adolescents twelve to eighteen a long time of age who produce other chance aspects that could maximize their sensitivity into the respiratory depressant consequences of codeine Unless of course the benefits outweigh the dangers.
Pediatric people ought to be supervised in order to avoid probable hurt in bicycle Driving or in other dangerous activities.
Codeine was not mutagenic inside the in vitro bacterial reverse mutation assay or clastogenic from the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay.
Clients ought to be recommended to measure Promethazine HCl Oral Answer by having an accurate measuring product. A house teaspoon just isn't an precise measuring product and could lead to overdosage, especially when a fifty percent a teaspoon is measured.